## Neuropilin-1 is a protein encoded by the NRP1 gene that nrp1 plays essential roles in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
Neuropilin-1 (NRP1) is a transmembrane glycoprotein (923 amino acids) with an extracellular domain containing:
NRP1 functions as a co-receptor for both VEGF and semaphorin ligands, forming complexes with tyrosine kinase receptors (VEGFR1/2) and plexin receptors.
NRP1 plays essential roles in:
NRP1 is implicated in AD pathogenesis through multiple mechanisms:
| Approach | Status | Notes |
|---|---|---|
| NRP1 agonists | Preclinical | Enhance VEGF signaling, BBB repair |
| NRP1 antagonists | Research | Block Aβ-NRP1 interaction |
| Peptide mimetics | Discovery | BDNF-loop mimetics in development |
| Gene therapy | Research | AAV-NRP1 delivery for neuroprotection |