Npas3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NPAS3 (Neuronal PAS Domain Protein 3) is a transcription factor expressed predominantly in the brain. As a member of the bHLH-PAS family, NPAS3 plays critical roles in neural development, circadian rhythm regulation, and cognitive function. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Protein Name | Neuronal PAS Domain Protein 3 | [4]
| Gene | NPAS3 | [5]
| UniProt ID | Q8TDW5 | [6]
| Molecular Weight | ~100 kDa | [7]
| Structure | bHLH-PAS domain architecture |
| Subcellular Localization | Nucleus |
NPAS3 contains:
NPAS3 is a potential target for:
The study of Npas3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kamnasaran et al. NPAS3 and brain development (2007). 2007. ↩︎
Erbel-Sieler et al. NPAS3/ARNT2 heterodimers (2004). 2004. ↩︎