Nme1 Protein Nucleoside Diphosphate Kinase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Nucleoside Diphosphate Kinase 1 | |
|---|---|
| Protein Name | Nucleoside Diphosphate Kinase 1 |
| Gene | NME1 |
| UniProt ID | P15531 |
| PDB ID | 1JTV |
| Molecular Weight | 17 kDa |
| Localization | Cytoplasm, nucleus |
| Protein Family | NDP kinase family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
NME1 is a hexameric enzyme:
NDPK1 maintains nucleotide pools:
Low NME1 - increased metastasis risk; prognostic marker
Often downregulated in metastases; tumor suppressor activity
NME1-based therapies under investigation; no direct drugs yet
The study of Nme1 Protein Nucleoside Diphosphate Kinase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.