Nmda Receptor Nr2A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| NMDA Receptor NR2A | NMDA Receptor NR2A Protein | GRIN2A | UniProt | 1466 aa | 165.3 kDa | Postsynaptic Membrane | Glutamate Receptor Family |
NMDA Receptor NR2A Protein is a protein involved in neuronal function and signaling relevant to neurodegenerative diseases. It plays important roles in synaptic transmission, ion channel regulation, or cellular metabolism that are critical for neuronal health and function.
Dysregulation of this protein's function or expression contributes to the pathogenesis of Alzheimer's disease, Parkinson's disease, and related neurodegenerative disorders through effects on synaptic plasticity, energy metabolism, or cellular stress response.
NMDA Receptor NR2A is a 1466 aa 165.3 kDa Postsynaptic Membrane protein belonging to the Glutamate Receptor Family. The protein is a G protein-coupled receptor (GPCR) with 7 transmembrane domains.
Ionotropic glutamate receptor, NMDA receptor, synaptic plasticity, excitotoxicity, LTP. These receptors are essential for fast excitatory neurotransmission in the brain.
Alzheimer's Disease: Glutamate receptor dysfunction contributes to excitotoxicity. Dopaminergic receptors are affected in AD with dementia.
Parkinson's Disease: D2 receptor agonists are mainstays of treatment. NMDA receptor antagonists (amantadine) help dyskinesias.
ALS: Excitotoxicity via glutamate receptors is a key mechanism. Riluzole targets glutamate transmission.
Schizophrenia: D2 receptor antagonists are antipsychotics. NMDA receptor dysfunction implicated.
The study of Nmda Receptor Nr2A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.