Nfkb2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NFKB2 (Nuclear Factor Kappa B Subunit 2), also known as p100 or p52, is a member of the NF-κB transcription factor family. NFKB2 is synthesized as a full-length p100 precursor that is processed to the active p52 subunit. It plays crucial roles in immune responses, inflammation, cell survival, and neuronal function. Dysregulation of NFKB2 is implicated in neurodegenerative diseases, cancer, and autoimmune disorders [1][2].
| Attribute | Value |
|---|---|
| Gene Symbol | NFKB2 |
| Protein Name | Nuclear Factor NF-kappa-B p100 subunit |
| Alternative Names | p100, p52, NF-κB2, LYT10 |
| UniProt ID | Q12986 |
| Molecular Weight | ~100 kDa (p100); ~52 kDa (p52) |
| Protein Family | NF-κB family |
| Subcellular Localization | Nucleus, cytoplasm |
NFKB2 has unique features:
Processing is constitutive or inducible via the NF-κB inducing kinase (NIK) [3].
NFKB2 functions in:
NFKB2 regulates:
In neurons:
NFKB2 in AD:
Targeting NFKB2:
The study of Nfkb2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bours V, et al. (1994). "NFKB2 (p100) is a transcription factor." Oncogene. ↩︎
Senftleben U, et al. (2001). "Activation by NF-κB by the alternative pathway." Science. ↩︎
Xiao G, et al. (2001). "NFKB2 processing by NIK." Mol Cell. ↩︎
O'Neill LA, et al. (2009). "NF-κB in neuronal function." Nat Rev Neurosci. ↩︎
Mattson MP, et al. (2012). "NFKB2 in neuroprotection." Cell Death Differ. ↩︎