Nf Κb P105 P50 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nf Κb P105 P50 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| NF-κB p105/p50 Protein | |
|---|---|
| Protein Name | NF-κB p105/p50 Protein |
| Gene | [NFKB1](/genes/nfkb1) |
| UniProt ID | [P19838](https://www.uniprot.org/uniprot/P19838) |
| PDB IDs | 1SVC, 1NFK, 2DBF |
| Molecular Weight | 105 kDa (p105), 50 kDa (p50) |
| Subcellular Location | Nucleus, Cytoplasm |
| Protein Family | [NF-κB](/entities/nf-kb) transcription factors |
NF-κB p105/p50 Protein is a NF-κB transcription factors. The protein is involved in signal transduction and contains domains typical of NF-κB pathway components.
NFKB1 encodes p105, which is processed to p50, a DNA-binding subunit of NF-κB. p50 lacks a transactivation domain and forms heterodimers with RELA or c-Rel to induce target gene expression. p50 homodimers can act as transcriptional repressors. NF-κB regulates immune response, inflammation, cell survival, and proliferation.
Dysregulated NF-κB signaling contributes to chronic inflammation in AD, PD, MS, and cancer. p50 deficiency enhances susceptibility to bacterial infection.
BAY 11-7082, IKK inhibitors (experimental), NF-κB DNA-binding decoys.
Nf Κb P105 P50 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nf Κb P105 P50 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy. 2023. ↩︎