| NF-kappaB | |
|---|---|
| Gene Family | RELA (p65), NFKB1 (p50), NFKB2 (p52), REL, RELB |
| UniProt | RELA, NFKB1 |
| PDB | 1MY7, 1NFI |
| Mol. Weight | p65: 55 kDa, p50: 50 kDa |
| Localization | Cytoplasm (inactive), Nucleus (active) |
| Family | NF-κB transcription factor family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, ALS, Multiple Sclerosis, Stroke |
Nf Kappab is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NF-kappaB (NF-κB) is a family of transcription factors that regulates genes involved in inflammation, cell survival, proliferation, and immune responses. In the central nervous system, NF-κB plays dual roles—physiologically regulating neuronal function and pathologically driving neuroinflammation in neurodegenerative diseases[1].
The NF-κB family consists of five related proteins:
These form various homodimers and heterodimers with distinct functions.
NF-κB regulates essential neuronal genes:
In microglia and astrocytes:
NF-κB activation in AD:
NF-κB in PD:
NF-κB in ALS:
NF-κB promotes:
NF-κB inhibitors being explored:
The study of Nf Kappab has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nature Immunology. 2002;3(3):221-227. PMID:11850721 ↩︎
Kaltschmidt B, Kaltschmidt C. NF-kappaB in the nervous system. Cold Spring Harbor Perspectives in Biology. 2009;1(3):a001271. PMID:20066083 ↩︎
Chen CH, Zhou W, Liu S. NF-κB as a therapeutic target in neurodegenerative diseases. Expert Opinion on Therapeutic Targets. 2012;16(8):805-828. PMID:22775423 ↩︎
Hunot S, Vila M, Teismann P, et al. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease. Proceedings of the National Academy of Sciences. 2004;101(1):101-106. PMID:14695885 ↩︎
Swarup V, Phaneuf D, Dupré N, et al. Deregulation of TDP-43 in the pathogenesis of Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences. 2011;12(12):8658-8673. PMID:22143420 ↩︎