Neurturin is a neurotrophic factor of the GDNF family that supports the survival and function of various neuronal populations, particularly those involved in motor control and autonomic function.
- Gene: NRTN
- UniProt ID: Q9NZH8
- Molecular Weight: ~20 kDa (mature form)
- Structure: Homodimer
- Family: GDNF family
- Subcellular Localization: Secreted
Neurturin shares the GDNF family structure:
- Secretory signal peptide
- Prodomain
- Mature homodimeric form
- Cysteine-knot structure
- Motor Neuron Support: Promotes motor neuron survival
- Enteric Neurons: Essential for enteric nervous system
- Sympathetic Neurons: Supports sympathetic neuron survival
- Dopaminergic Protection: Can protect midbrain dopaminergic neurons
Neurturin signals through GFRα2/RET receptor complex:
- GFRα2 (GFRA2) - primary binding
- RET - transduces signals
- PI3K/Akt and MAPK/ERK pathways
Neurturin has been tested in clinical trials (CERE-120) for dopaminergic neuron protection. Results showed some benefit in motor function [1].
NRTN shows protective effects in striatal neurons in HD models [2].
Protective against chemotherapy-induced peripheral neuropathy [3].
- Gene Therapy: AAV-NRTN (CERE-120)
- Protein Delivery: Recombinant neurturin
- Cell Therapy: NRTN-secreting cells
- Kotzbeck et al., NRTN trials (2023)
- Gasmi et al., NRTN in HD (2022)
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
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