## NEIL3 is a protein encoded by the NEIL3 gene that neil3 is a dna glycosylase that plays a critical role in the base excision repair pathway:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
NEIL3 contains a characteristic Fpg/Nei family DNA glycosylase domain with:
The enzyme recognizes and removes damaged bases including oxidized purines and pyrimidines through a base excision repair (BER) mechanism[1].
NEIL3 is a DNA glycosylase that plays a critical role in the base excision repair pathway:
Liu M, et al. Structure and function of NEIL3 DNA glycosylase. J Biol Chem. 2018. ↩︎
Seiler JA, et al. NEIL3: The DNA glycosylase that protects neural stem cells. DNA Repair. 2018. ↩︎