Naglu Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Alpha-N-Acetylglucosaminidase |
|---|---|
| Gene | NAGLU |
| UniProt ID | |
| P54802 | |
| PDB ID | 4MKV, 4O3G |
| Molecular Weight | 73.9 kDa |
| Subcellular Localization | Lysosome |
| Protein Family | _family 89, NAGLU |
NAGLU is a 73.9 kDa lysosomal enzyme:
NAGLU is a lysosomal enzyme involved in glycosaminoglycan degradation:
Primary functions:
2.能
Parenti G, et al. (2015). "Lysosomal storage diseases: from pathophysiology to therapy." Adv Genet. 90:1-50.
The study of Naglu Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
NAGLU encodes Alpha-N-Acetylglucosaminidase, a lysosomal enzyme deficient in Sanfilippo syndrome B. Causes neurodegeneration in childhood.