Naga Protein Alpha N Acetylgalactosaminidase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Alpha-N-Acetylgalactosaminidase | |
|---|---|
| Protein Name | Alpha-N-Acetylgalactosaminidase |
| Gene | NAGA |
| UniProt ID | P17050 |
| PDB ID | 2JEV |
| Molecular Weight | 46 kDa |
| Localization | Lysosome |
| Protein Family | Glycoside hydrolase family 27 |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
NAGA is a homodimeric enzyme:
NAGA catalyzes removal of alpha-N-acetylgalactosamine:
NAGA deficiency - neurodevelopmental abnormalities, seizures
Adult-onset variant - angiokeratoma, neuropathy
Enzyme replacement therapy under development; gene therapy approaches explored
The study of Naga Protein Alpha N Acetylgalactosaminidase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.