Ms4A6E Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
MS4A6E (Membrane Spanning 4-Domains A6E) is a member of the membrane-spanning 4-domain family. GWAS have identified MS4A6E as a genetic risk factor for late-onset Alzheimer's disease (LOAD). MS4A6E is expressed in immune cells and may be involved in microglial function and neuroinflammation in AD.
MS4A6E (Membrane Spanning 4-Domains A6E) is a member of the membrane-spanning 4-domain family A (MS4A) cluster on chromosome 11. GWAS have consistently identified MS4A6E as a genetic risk factor for late-onset Alzheimer's disease (LOAD). The MS4A gene cluster contains at least 16 genes encoding proteins with similar transmembrane topologies. MS4A6E is primarily expressed in immune cells including microglia in the brain, where it may modulate cell surface receptor function and signaling. The mechanism by which MS4A6E variants influence AD risk involves modulation of microglial activation and neuroinflammatory responses.
MS4A6E contains four transmembrane domains with both N- and C-termini located in the cytoplasm. The extracellular loops are relatively short. MS4A proteins are thought to function as ion channels or receptors. The structure is similar to other MS4A family members.
MS4A6E (Membrane Spanning 4-Domains A6E) is a member of the membrane-spanning 4-domain family. GWAS have identified MS4A6E as a genetic risk factor for late-onset Alzheimer's disease (LOAD). MS4A6E is expressed in immune cells and may be involved in microglial function and neuroinflammation in AD.
In Alzheimer's disease, MS4A6E variants influence AD risk. The mechanism is not fully understood but may involve modulation of microglial activation and neuroinflammation. MS4A6E is expressed in brain immune cells and may regulate cytokine production.
No MS4A6E-targeted therapies exist. Further research is needed to understand its function and develop therapeutic strategies targeting MS4A6E in AD.
The study of Ms4A6E Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.