## Structure is a protein that ### Mitochondrial Fission Regulation. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
MiD49 is anchored to the mitochondrial outer membrane via a single transmembrane helix:
MiD49 shares structural similarity with MiD50 and functions as a molecular scaffold for the mitochondrial fission machinery[1].
MiD49 is a key regulator of mitochondrial fission:
MiD49 participates in mitochondrial quality control pathways:
MiD49 interacts with several key mitochondrial proteins:
MiD49 dysfunction contributes to Parkinson's disease pathogenesis:
In Alzheimer's disease, MiD49 is involved in:
MiD49 abnormalities in ALS include:
MiD49 is an emerging therapeutic target:
| Approach | Status | Description |
|---|---|---|
| Small molecule modulators | Preclinical | Compounds that modulate MiD49-Drp1 interaction |
| Gene therapy | Research | Modulating MiD49 expression for mitochondrial health |
| Kinase inhibitors | Research | Targeting kinases that phosphorylate MiD49 |
Loson OC, Song Z, Chen H, Chan DC. MiD49 and MiD50 are mitochondrial outer membrane proteins that recruit Drp1 to mitochondria. Journal of Cell Biology. 2014. ↩︎
Palmer CS, Osellame LD, Stojanovski D, Ryan MT. The regulation of mitochondrial dynamics. The FEBS Journal. 2011. ↩︎
Wang X, Winter D, Ashrafi G, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 2011. ↩︎