Mecp2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Mecp2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| Protein Name | Methyl-CpG Binding Protein 2 |
|---|---|
| Gene | [MECP2](/genes/mecp2) |
| UniProt ID | P51608 |
| PDB ID | 1QK9, 1IGC, 3C2I |
| Molecular Weight | 52.4 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | Methyl-CpG binding domain (MBD) family |
MeCP2 is a 52.4 kDa nuclear protein with distinct functional domains:
The protein can bind to:
MeCP2 is a transcriptional repressor and regulator that plays critical roles in neuronal development and function:
Primary functions:
Target genes:
Expression:
Amir RE, et al. (1999). "Rett syndrome is caused by mutations in X-linked MECP2." Nat Genet. 23(2):185-188. DOI:10.1038/13810
Guy J, et al. (2001). "A candidate mouse model for Rett syndrome." Nature. 413(6855):473-475.
Chahrour M, et al. (2008). "MeCP2, a key contributor to neurological disease, activates and represses transcription." Science. 320(5880):1224-1229.
Mecp2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Mecp2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.