Max Protein (Max) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| MAX Protein | |
|---|---|
| Gene | MAX |
| UniProt ID | P61275 |
| PDB ID(s) | 1A93, 1NLW |
| Molecular Weight | 21 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | bHLH-LZ Transcription Factor Family |
| Transcription factor, Myc/Max/Mad network member | |
| Associated Diseases | Neuroblastoma, Burkitt Lymphoma, Alzheimer's Disease, Parkinson's Disease |
MAX is a bHLH-LZ transcription factor that serves as the central hub of the Myc/Max/Mad network. MAX-MYC heterodimers activate proliferation genes while MAX-MAD heterodimers repress them. In neurons, MAX regulates synaptic plasticity genes and controls apoptosis. The Myc/Max network is dysregulated in neurodegenerative diseases, contributing to neuronal dysfunction and death.
MAX belongs to the bHLH-LZ Transcription Factor Family. The protein contains:
The three-dimensional structure has been solved (1A93, 1NLW), revealing insights into mechanism and drug binding.
MAX plays critical roles in normal neuronal function:
Dysregulation of MAX contributes to neurodegenerative processes through several mechanisms:
Therapeutic strategies targeting MAX include:
| Approach | Status | Notes |
|---|---|---|
| Small molecule inhibitors | Preclinical | Various compounds in development |
| Epigenetic modulators | Research | Broader specificity |
| Gene therapy | Experimental | AAV-delivered functional copies |
| Protein-protein interaction inhibitors | Research | Targeting complex formation |
MAX expression and activity can be measured in:
The study of Max Protein (Max) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.