Map7 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Microtubule Associated Protein 7 |
| Gene Symbol | MAP7 |
| UniProt ID | Q9Y5H5 |
| Molecular Weight | ~55 kDa |
| Subcellular Localization | Cytoplasm, Cytoskeleton |
| Protein Family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
| Microtubule-associated protein family |
The MAP7 protein is a member of the microtubule-associated protein family. It contains multiple repeats that mediate microtubule binding and interactions with other cytoskeletal proteins.
MAP7 encodes a microtubule-associated protein that promotes microtubule polymerization and stabilizes microtubule networks. It interacts with kinesin motors and is involved in intracellular transport, cell polarity, and neuronal morphogenesis.
ALS: MAP7 mutations have been linked to familial ALS.
Charcot-Marie-Tooth Disease: Associated with peripheral neuropathy.
Axonal Transport: Critical for transport of cargoes in neurons.
Research into therapeutic targeting of MAP7 is ongoing. Understanding its role in neurodegeneration may lead to novel therapeutic interventions.
The study of Map7 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.