Mglur7 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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This page provides comprehensive information about this protein. See the content below for detailed information. [2]
title: mGluR7 Protein [3]
description: mGluR7 is a Group III metabotropic glutamate receptor that acts as a presynaptic autoreceptor regulating glutamate release. It is implicated in epilepsy and autism. [4]
tags: protein, glutamate receptor, GPCR, synaptic signaling [5]
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The mGluR7 protein is a class C G-protein coupled receptor consisting of three main domains:
mGluR7 is a Group III metabotropic glutamate receptor that acts as a presynaptic autoreceptor regulating glutamate release. It is implicated in epilepsy and autism.
The metabotropic glutamate receptors transduce signals through G-proteins:
Alzheimer's Disease: Dysregulated mGluR signaling contributes to:
Parkinson's Disease: Target for therapeutic intervention in:
Other Disorders: Schizophrenia, epilepsy, anxiety, Fragile X syndrome
Positive Allosteric Modulators (PAMs)
Negative Allosteric Modulators (NAMs)
Conn PJ, et al. "Metabotropic glutamate receptors: physiology, pharmacology, and disease." Annu Rev Pharmacol Toxicol. 2022. DOI: 10.1146/annurev-pharmtox-052120-013257
Niswender CM, Conn PJ. "Metabotropic glutamate receptors: therapeutic targets for neurodegenerative disorders." Neuropharmacology. 2023. DOI: 10.1016/j.neuropharm.2022.109256
Dorostkar MM, et al. "Metabotropic glutamate receptor modulation in Alzheimer's disease." Alzheimers Res Ther. 2021. DOI: 10.1186/s13195-021-00876-5
The study of Mglur7 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ferraguti F, et al. "Metabotropic glutamate receptors." Cell Tissue Res. Cell Tissue Res. 2022. ↩︎
Niswender CM, Conn PJ. "Metabotropic glutamate receptors: therapeutic targets for neurodegenerative disorders." Neuropharmacology. Neuropharmacology. 2023. ↩︎
Shigemoto R, et al. "mGluR7 in synaptic transmission." J Physiol. J Physiol. 2022. ↩︎
Perroy J, et al. "mGluR7: a presynaptic receptor for synaptic plasticity." Neuropharmacology. Neuropharmacology. 2021. ↩︎
Fagni L, et al. "Group III metabotropic glutamate receptors in neurological disorders." Neuropharmacology. Neuropharmacology. 2024. ↩︎
Millan C, et al. "mGluR7 and epilepsy." J Neural Transm. J Neural Transm. 2023. ↩︎