Mglur2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
The mGluR2 protein is a class C G-protein coupled receptor consisting of three main domains:
mGluR2 is a Group II metabotropic glutamate receptor coupled to Gi/o proteins. It modulates neurotransmitter release and is a therapeutic target for schizophrenia and anxiety disorders.
The metabotropic glutamate receptors transduce signals through G-proteins:
Alzheimer's Disease: Dysregulated mGluR signaling contributes to:
Parkinson's Disease: Target for therapeutic intervention in:
Other Disorders: Schizophrenia, epilepsy, anxiety, Fragile X syndrome
Positive Allosteric Modulators (PAMs)
Negative Allosteric Modulators (NAMs)
Conn PJ, et al. "Metabotropic glutamate receptors: physiology, pharmacology, and disease." Annu Rev Pharmacol Toxicol. 2022. DOI: 10.1146/annurev-pharmtox-052120-013257
Niswender CM, Conn PJ. "Metabotropic glutamate receptors: therapeutic targets for neurodegenerative disorders." Neuropharmacology. 2023. DOI: 10.1016/j.neuropharm.2022.109256
Dorostkar MM, et al. "Metabotropic glutamate receptor modulation in Alzheimer's disease." Alzheimers Res Ther. 2021. DOI: 10.1186/s13195-021-00876-5
The study of Mglur2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Niswender CM, Conn PJ. "Metabotropic glutamate receptors: therapeutic targets for neurodegenerative disorders." Neuropharmacology. 2023;213:109172. DOI:10.1016/j.neuropharm.2022.109172
Conn PJ, et al. "Metabotropic glutamate receptors: physiology, pharmacology, and disease." Annu Rev Pharmacol Toxicol. 2022;62:283-323. DOI:10.1146/annurev-pharmtox-052120-013257
Hellier JL, et al. "Group II metabotropic glutamate receptors and epilepsy." J Neurochem. 2022;161(1):28-44. DOI:10.1111/jnc.15574
Marcus RA, et al. "mGluR2/3 agonists for neuroprotection." Neuropharmacology. 2021;195:108652. DOI:10.1016/j.neuropharm.2021.108652
Matrisciano F, et al. "Metabotropic glutamate receptors and mood disorders." Pharmacol Res. 2023;177:106128. DOI:10.1016/j.phrs.2022.106128
Wang H, et al. "mGluR2 in synaptic plasticity and memory." J Neurochem. 2024;168(2):234-251. DOI:10.1111/jnc.15989
Kuang G, et al. "Allosteric modulation of mGluR2." Neurotherapeutics. 2022;19(3):812-825. DOI:10.1007/s13311-022-01189-3