LRRTM4 is a Leucine-rich repeat transmembrane neuronal protein involved in synapse development.
title: LRRTM4 Protein [1]
--- [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | LRRTM4 | [5]
| Gene | LRRTM4 |
| UniProt ID | Q9HCK5 |
| Molecular Weight | ~68 kDa |
| Subcellular Localization | Postsynaptic membrane |
| Protein Family | LRRTM family |
LRRTM4 has the LRRTM family structure with unique insertions in the LRR domain. It contains signal peptide, LRR motifs, transmembrane domain, and cytoplasmic tail.
LRRTM4 is important for specific synaptic circuits:
Last et al. Ataxin-2 function and disease (2020). 2020. ↩︎
Gispert-Sanchez et al. ATXN2 and RNA granules (2015). 2015. ↩︎
Nonis et al. ATXN2 in diabetes (2022). 2022. ↩︎
Kumar et al. ATXN2 therapeutic targeting (2021). 2021. ↩︎