{{> infobox .infobox-protein
| name = LITAF Protein
| gene = LITAF
| uniprot = Q12941
| pdb = 2N93
| molecular_weight = ~17 kDa
| localization = Cytoplasm, Endosome, Lysosome
| family = LITAF domain family
}}
{{> infobox is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
LITAF (Lipopolysaccharide-Induced TNF Factor) is a small soluble protein (~175 amino acids) containing a conserved LITAF domain characterized by a zinc finger-like structure. The protein forms homodimers and heterodimers through its C-terminal domain. LITAF lacks a transmembrane domain but associates with intracellular membranes through protein-protein interactions.
LITAF is expressed in neurons and glial cells, where it functions in:
[1] LITAF mutations are linked to ALS through:
[2] In PD, LITAF contributes to:
[3] LITAF is upregulated in AD brains and may contribute to: