Lingo1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| LINGO1 |
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| LINGO1 Protein |
| Protein Name | LINGO1 Protein |
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| Gene | LINGO1 |
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| UniProt ID | Q9BZN1 |
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| PDB ID | N/A |
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| Molecular Weight | 63 kDa |
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| Subcellular Localization | Plasma membrane |
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| Protein Family | Leucine-rich repeat and immunoglobulin-like domain family |
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LINGO1 (Leucine-Rich Repeat and Immunoglobulin-Like Domain-Containing Neurite Outgrowth Inhibitor Protein) is a transmembrane protein that is a key negative regulator of axonal regeneration in the central nervous system.
LINGO1 is a 581-amino acid protein with:
- Extracellular leucine-rich repeat (LRR) domain
- Immunoglobulin-like (Ig) domain
- Single transmembrane helix
- Intracellular cytoplasmic tail
LINGO1 negatively regulates:
- Axonal regeneration after CNS injury
- Oligodendrocyte differentiation
- Myelin formation
- Neurite outgrowth
- LINGO1 inhibitors promote remyelination
- Blocking LINGO1 enhances recovery in MS models
- Clinical trials of LINGO1 antibodies ongoing
- May affect dopaminergic neuron survival
- Altered expression in PD models
- Affects synaptic plasticity
- May interact with tau pathology
- Monoclonal antibodies against LINGO1 in clinical trials
- Promotes remyelination in preclinical models
- Potential for neural repair therapies
- Mi et al. (2007). "LINGO-1 antagonist promotes spinal cord remyelination." Nat Neurosci. PMID: 17558406
The study of Lingo1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Mi et al. (2007). "LINGO-1 antagonist promotes spinal cord remyelination." Nat Neurosci. PMID: 17558406
- Jepson et al. (2014). "LINGO1 in health and disease." Nat Rev Neurol. PMID: 24619417
- Bankston et al. (2013). "LINGO-1 regulates oligodendrocyte differentiation." J Neurosci. PMID: 23536098
- Schwab et al. (2006). "Nogo and NgR in CNS regeneration." Nat Med. PMID: 16736024