LIMP2 (SCARB2) is a lysosomal transmembrane protein critical for glucocerebrosidase trafficking to lysosomes. It serves as a receptor for glucocerebrosidase and other lysosomal enzymes. LIMP2 deficiency causes a form of Gaucher disease and is linked to Parkinson's disease risk.
LIMP-2 Protein is encoded by the LIMP2 gene. It is a Lysosomal transmembrane receptor, scavenger receptor with a molecular weight of approximately 525 aa. The protein localizes to Lysosomal membrane.
The LIMP-2 Protein contains characteristic domains for its function as a Lysosomal transmembrane receptor, scavenger receptor. Structural information is available from UniProt and the PDB.
LIMP2 (SCARB2) is a lysosomal transmembrane protein critical for glucocerebrosidase trafficking to lysosomes. It serves as a receptor for glucocerebrosidase and other lysosomal enzymes. LIMP2 deficiency causes a form of Gaucher disease and is linked to Parkinson's disease risk.
Dysfunction of LIMP-2 Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of LIMP-2 Protein includes: