Lamtor2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Protein Name | LAMTOR2 (Late Endosomal/Lysosomal Adaptor, MAPK and mTOR Activator 2) |
| Gene Symbol | LAMTOR2 |
| Aliases | LAMTOR2, p14, MAPKSP1 |
| UniProt ID | Q9Y2Q5 |
| Molecular Weight | 161 aa (~18 kDa |
| Subcellular Localization | Late endosomes, lysosomes, ragulator complex |
| Protein Family | LAMTOR family |
LAMTOR2 is an essential component of the Ragulator complex, a key regulator of mTORC1 signaling:
LAMTOR2 forms a heteropentameric complex with LAMTOR1 (p18), LAMTOR3 (p14), LAMTOR4 (HBXIP), and LAMTOR5. This complex localizes to the surface of late endosomes and lysosomes.
The Ragulator complex serves multiple critical functions:
Beyond mTORC1, LAMTOR2 also modulates MAPK/ERK signaling through its interactions with scaffold proteins.
LAMTOR2 is crucial for proper lysosomal function. Mutations in LAMTOR genes cause primary lysosomal storage disorders characterized by accumulation of undegraded materials.
| Property | Value |
|---|---|
| Chromosome | 1 |
| Location | 1p31.3 |
| NCBI Gene ID | 261726 |
| Ensembl ID | ENSG00000116586 |
| Strategy | Description | Status |
|---|---|---|
| mTOR Inhibitors | Rapamycin to overcome mTORC1 dysregulation | FDA-approved for TSC |
| Lysosomal Function Enhancers | Restore proper ragulator/lysosomal function | Preclinical |
| Autophagy Inducers | Bypass ragulator defects to enhance protein clearance | Clinical trials |
Sancak Y et al. "The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1." Science. 2008;320(5882):1496-1501. PMID:18497260
Bar-Peled L et al. "Ragulator is a GEF for the Rag GTPases that activates mTOR by recruiting it to lysosomes." Cell. 2013;151(6):1256-1269. PMID:24204285
Zoncu R et al. "mTOR: from growth signal integration to cancer, diabetes and ageing." Nat Rev Mol Cell Biol. 2011;12(1):21-35. PMID:21157483
Kim J et al. "mTOR regulates cell growth and autophagy in neurodegeneration." Nat Rev Neurosci. 2021;22(5):281-297. PMID:33772229
Settembre C et al. "A block in autophagy: a common pathogenic mechanism in neurodegenerative diseases." Autophagy. 2012;8(4):555-564. PMID:22370611
The study of Lamtor2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.