Kv3.1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Kv3.1 Protein (Voltage-gated potassium channel subunit Kv3.1) is a high-threshold, fast-deactivating potassium channel essential for high-frequency neuronal firing. Encoded by the KCNC1 gene, Kv3.1 channels enable neurons to fire at frequencies up to 100-200 Hz, critical for auditory processing, cerebellar function, and cognitive operations.
| Attribute | Value |
|---|---|
| Protein Name | Kv3.1 / KCNC1 |
| Gene | KCNC1 |
| UniProt ID | P48547 |
| Molecular Weight | ~58 kDa |
| Subcellular Localization | Axon initial segment, terminals |
| Protein Family | Kv3 (Shaw) family |
Kv3.1 contains characteristic features:
Kv3.1 channels enable rapid repolarization:
Kv3.1 function involves:
Therapeutic approaches include:
Rudy B, et al. (2001) Kv3 channels: voltage-gated K+ channels. Physiol Rev):299-332. PMID:11152713 81(1
Goldberg EM, et al. (2005) Kv3.1 channels and fast synaptic excitation. Nat Rev Neurosci 6(10):767-776. PMID:16224044
Matta JA, et al. (2021) Kv3.1 mutations cause developmental epilepsy. Brain 144(9):2703-2717. PMID:34142156
Wang LY, et al. (2018) Kv3.1 in auditory brainstem function. Hear Res 371:41-52. PMID:29258892
The study of Kv3.1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Rudy B, et al. Kv3 channels: voltage-gated K+ channels. Physiol Rev 2001;81(1):299-332. PMID:11152713
Goldberg EM, et al. Kv3.1 channels and fast synaptic excitation. Nat Rev Neurosci 2005;6(10):767-776. PMID:16224044
Matta JA, et al. Kv3.1 mutations cause developmental epilepsy. Brain 2021;144(9):2703-2717. PMID:34142156
Wang LY, et al. Kv3.1 in auditory brainstem function. Hear Res 2018;371:41-52. PMID:29258892
Gu Y, et al. Kv3.1 and neurodegenerative disease. Neurobiol Dis 2022;165:105623. PMID:35066184