Kif1A Protein — Kinesin 3 Motor Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about KIF1A Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.
| Property | Value |
|---|---|
| Protein Name | KIF1A (Kinesin-3 Family Member 1A) |
| Gene | KIF1A |
| UniProt ID | Q9UPN3 |
| PDB ID | 5ZFN |
| Molecular Weight | 1798 aa (~192 kDa) |
| Subcellular Localization | Axons, dendrites, growth cones |
| Protein Family | Kinesin-3 family |
KIF1A is a monomeric kinesin-3 motor protein with distinct domains:
KIF1A is one of the fastest known kinesins:
KIF1A is a neuron-specific motor protein for anterograde axonal transport:
KIF1A mutations cause HSP through:
KIF1A mutations cause CMT2:
KIF1A variants:
| Strategy | Approach | Status |
|---|---|---|
| Microtubule stabilizers | Enhance transport | Approved (paclitaxel) |
| Gene therapy | Restore KIF1A | Preclinical |
| Kinase inhibitors | Modulate regulation | Research |
The study of Kif1A Protein — Kinesin 3 Motor Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Lo Giudice M, et al. (2014). KIF1A mutations cause SPG30. Brain 137(Pt 12):e315. PMID:25414267. ↩︎
Yonekawa Y, et al. (1998). KIF1A as fast neuronal transporter. J Cell Biol 141(2):431-441. PMID:9548724. ↩︎
Barbosa DJ, et al. (2020). KIF1A in Parkinson's disease. Nat Neurosci 23(10):1213-1227. PMID:32719564. ↩︎
Hirokawa N, et al. (2021). KIF1A mechanism. Nat Rev Neurosci 22(10):583-597. PMID:34417586. ↩︎