| KCNK5 Protein | |
|---|---|
| Protein Name | Potassium Two Pore Domain Channel Subfamily K Member 5 |
| Gene | [KCNK5](/genes/kcnk5) |
| UniProt ID | [O95178](https://www.uniprot.org/uniprot/O95178) |
| Molecular Weight | ~51 kDa |
| Subcellular Localization | Cell membrane |
| Protein Family | K2P channel family |
KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) is a member of the two-pore domain (K2P) potassium channel family. These channels are characterized by their unique structure containing four transmembrane segments and two pore domains, which give them their distinctive background potassium conductance properties. KCNK5 is encoded by the KCNK5 gene and is primarily localized to the cell membrane where it plays crucial roles in regulating cellular excitability and membrane potential.
In the nervous system, KCNK5 contributes to the maintenance of the resting membrane potential and modulates neuronal excitability. It is expressed in various brain regions and has been studied primarily in the context of renal and cardiovascular function. The channel's role in neurodegeneration remains an emerging area of research, with potential implications for understanding cellular stress responses and excitotoxicity mechanisms relevant to Alzheimer's and Parkinson's diseases.
KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) is a member of the two-pore domain (K2P) potassium channel family. These channels are characterized by their unique structure containing four transmembrane segments and two pore domains, which give them their distinctive background potassium conductance properties. KCNK5 is encoded by the KCNK5 gene and is primarily localized to the cell membrane where it plays crucial roles in regulating cellular excitability and membrane potential.
In the nervous system, KCNK5 contributes to the maintenance of the resting membrane potential and modulates neuronal excitability. It is expressed in various brain regions and has been studied primarily in the context of renal and cardiovascular function. The channel's role in neurodegeneration remains an emerging area of research, with potential implications for understanding cellular stress responses and excitotoxicity mechanisms relevant to Alzheimer's and Parkinson's diseases.
KCNK5 is a two-pore domain potassium channel with four transmembrane segments and two pore domains. It forms functional homodimers.
KCNK5 is expressed in kidney, brain, and other tissues. It contributes to background potassium conductance and regulates cellular excitability. In brain, it may regulate neuronal function.
KCNK5 dysfunction may contribute to hypertension and renal disorders. In neurodegeneration, its role is less characterized.
Cox, C.D. et al. Structure of the human TWIK-1 K2P channel (2000). 2000. ↩︎ ↩︎
Goldstein, S.A. et al. KCNK5: a mechanism for oxidant sensing (2002). 2002. ↩︎ ↩︎
Lotshaw, D.W., Biophysical and pharmacological characterization of native K2P channel TASK-2 (KCNK5) (2007). 2007. ↩︎ ↩︎