Kcnd2 Protein (Kv4.2 Potassium Channel) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| KCND2 Protein (Kv4.2 Potassium Channel) | |
|---|---|
| Gene | KCND2 |
| UniProt | Q9NSA2 |
| Molecular Weight | ~72 kDa |
| Subcellular Localization | Plasma membrane |
| Protein Family | Voltage-gated potassium channel family |
| Aliases | Kv4.2, KShIV |
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KCND2 (Kv4.2) is a voltage-gated potassium channel. It forms homotetramers or heterotetramers with Kv4.1 and Kv4.3. The channel has rapid activation and inactivation kinetics.
Kv4.2 regulates:
Kv4.2 dysfunction contributes to epilepsy:
Kv4.2 is altered in AD:
Kv4.2 variants are associated with ASD.
Kv4.2 modulators are being explored for:
The study of Kcnd2 Protein (Kv4.2 Potassium Channel) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hille B. Ion Channels of Excitable Membranes. 3rd ed. Sunderland, MA: Sinauer Associates; 2001.
Raggenbass M. Overview of principal ion channels and receptors in the CNS. In: Reference Module in Biomedical Sciences. Elsevier; 2018.
Caterina MJ. Voltage-gated calcium channels. In: Encyclopedia of Biological Chemistry. 2013:701-705.
Yu FH, Catterall WA. Overview of the voltage-gated sodium channel family. Genome Biol. 2003;4(3):207.
Sharker SM, Hattori M. Structure and function of voltage-gated potassium channels. In: Alkondon M, ed. Potassium Channels. IntechOpen; 2019.
The KCND2 Protein is involved in various cellular processes in the nervous system. This entity plays important roles in neuronal function, gene expression regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The KCND2 Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades.
Alterations in KCND2 Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this entity may serve as a therapeutic target for disease modification in AD, PD, and related disorders.