Kcna10 Protein Kv1.10 Potassium Channel is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| KCNA10 Protein | |
|---|---|
| Protein Name | Potassium voltage-gated channel subfamily A member 10 |
| Gene | [KCNA10](/genes/kcna10) |
| Category | Protein |
| Path | /proteins/kcna10-protein |
| UniProt ID | P16389 |
| Protein Family | Voltage-gated potassium channel (Kv1) |
KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a voltage-gated potassium channel protein that plays essential roles in neuronal excitability, cardiac function, and cellular repolarization. This channel belongs to the Shaker-like Kv1 family, characterized by six transmembrane domains and a pore-forming region. KCNA10 is unique among neuronal potassium channels due to its functional expression in both neuronal and cardiac tissues, making it particularly relevant for understanding excitability disorders.
KCNA10 forms homomeric or heteromeric voltage-gated potassium channels that:
In neurons, KCNA10 contributes to:
In cardiac tissue:
KCNA10 channel activity is modulated by:
Dysregulation of KCNA10 is implicated in:
KCNA10 contains the canonical Kv channel architecture:
TMD1 - TMD2 - TMD3 - Pore - TMD4 - TMD5 - TMD6
Each subunit features:
KCNA10 interacts with key cellular signaling systems:
KCNA10 interacts with:
KCNA10 represents a potential therapeutic target for:
Current research focuses on:
The study of Kcna10 Protein Kv1.10 Potassium Channel has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.