Itgam Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Integrin alpha-M (CD11B) |
|---|---|
| Gene | [ITGAM](/genes/itgam) |
| UniProt ID | [https://www.uniprot.org/uniprot/P05106 P05106] |
| PDB Structures | [1M1X](https://www.rcsb.org/structure/1M1X), [4G1M](https://www.rcsb.org/structure/4G1M) |
| Molecular Weight | 126,709 Da |
| Subcellular Localization | Plasma membrane |
| Protein Family | Integrin alpha family |
ITGAM is a 1153-amino acid protein with:
The study of Itgam Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The ITGAM Protein is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The ITGAM Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in ITGAM Protein expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.