Isg15 Protein — Interferon Stimulated Gene 15 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ISG15 Protein | |
|---|---|
| Gene | ISG15 (1p36.33) |
| UniProt | P51959 |
| Molecular Weight | ~15.8 kDa |
| Protein Family | Ubiquitin-like (Ubl) family |
| Subcellular Localization | Cytoplasm, nucleus |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
ISG15 is a 165-amino acid ubiquitin-like protein that shares approximately 30% sequence identity with ubiquitin. Like ubiquitin, ISG15 contains a C-terminal double glycine motif that is essential for conjugation to target proteins. The protein fold is similar to ubiquitin, consisting of a β-grasp fold.
ISG15 functions as a:
The ISGylation pathway involves:
In neurodegenerative diseases, ISG15 is often upregulated as part of the inflammatory response:
The study of Isg15 Protein — Interferon Stimulated Gene 15 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.