## IL-18 is a protein encoded by the IL18 gene that il-18 is a potent pro-inflammatory cytokine:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
IL-18 is a pro-inflammatory cytokine structurally related to IL-1β:
IL-18 is a potent pro-inflammatory cytokine:
| Agent | Type | Status | Indication |
|---|---|---|---|
| GSK-1070806 | Neutralizing antibody | Clinical | Inflammatory diseases |
| IL-18BP | Decoy receptor | Preclinical | AD, PD |
| Caspase-1 inhibitors | Enzyme inhibitor | Preclinical | Reduce IL-18 activation |
Dinarello CA, et al. IL-18: a Th1-promoting, proinflammatory cytokine. J Leukoc Biol. 1998. ↩︎
Sugama S, et al. IL-18 in neurological disorders. Curr Pharm Des. 2010. ↩︎