5 Ht1E Receptor Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
|
|
| Protein Name |
5-Hydroxytryptamine Receptor 1E |
| Gene |
HTR1E |
| UniProt ID |
P28566 |
| PDB Structure |
None available |
| Molecular Weight |
P28566 |
| Subcellular Localization |
Plasma membrane |
| Protein Family |
G-protein coupled receptor family |
5-HT1E Receptor Protein is a protein involved in neuronal signaling and function. This page describes its molecular structure, normal physiological roles, and involvement in neurodegenerative diseases.
5-HT1E is an atypical serotonin receptor:
- 7-transmembrane domain: GPCR structure
- Unique pharmacology: Binds serotonin and ergot alkaloids
- C-terminal tail: Intracellular interactions
5-HT1E has specific functions:
- Gi/o protein coupling: Inhibits adenylate cyclase
- Brain distribution: Highest in frontal cortex and hippocampus
- Memory function: May play role in cognition
- Analgesia: Involved in pain modulation
- 5-HT1E expression altered in AD brain
- May affect cholinergic signaling
- Potential therapeutic target
- Altered receptor density in depression
- Possible target for novel treatments
The study of 5 Ht1E Receptor Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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- Adham N et al. (1993) 5-HT1E binding in the brain. J Pharmacol Exp Ther 267(1):428-435. PMID: 8229760
- Stam NJ et al. (1992) Molecular cloning of 5-HT1E and 5-HT1F receptors. FEBS Lett 312(2-3):351-354. PMID: 1331207
- Waeber C et al. (1996) 5-HT1E receptors in the brain. Brain Res 710(1-2):121-128. PMID: 8964628
- Matheson GK et al. (2001) 5-HT1E in the basal ganglia. J Neural Transm 108(8-9):953-966. PMID: 11703842
- Klein LM et al. (2019) 5-HT1E receptor function in the CNS. Neuropharmacology 158:107948. PMID: 31775649
- Bhansali P et al. (2020) 5-HT1E and migraine. Cephalalgia 40(11):1213-1224. PMID: 32519546