Hif 1 Alpha is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **HIF-1 Alpha**
! Protein Name
| HIF-1 Alpha
! Gene
| [HIF1A](/genes/hif1a)
! UniProt ID
| [Q16665](https://www.uniprot.org/uniprot/Q16665)
! PDB IDs
| 1H2M, 4H6J
! Molecular Weight
| 92.6 kDa
! Subcellular Localization
| Nucleus, Cytoplasm
! Protein Family
| HIF family
HIF-1 Alpha (HIF1A) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.
HIF-1alpha has an N-terminal bHLH domain, PAS domains, and transactivation domains.
HIF-1alpha is a transcription factor that regulates genes involved in hypoxia adaptation, including glycolysis, angiogenesis, and erythropoiesis. It heterodimerizes with HIF-1beta (ARNT).
Chronic HIF activation or dysregulation is implicated in neurodegeneration. Both neuroprotective and detrimental effects have been reported.
HIF prolyl hydroxylase inhibitors (roxadustat, vadadustat) are approved for anemia. Protective in some neurodegeneration models.
The study of Hif 1 Alpha has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3):399-408. PMID: 22304911
- Wang GL et al. (1995) Hypoxia-inducible factor 1. Proc Natl Acad Sci USA 92(12):5510-5514. PMID: 7539918
- Sharp FR et al. (2004) HIF-1 and hypoxic preconditioning. J Cereb Blood Flow Metab 24(11):1247-1262. PMID: 15545690
- Zhang H et al. (2008) HIF-1 and mitochondrial dysfunction. Nat Rev Cancer 8(1):51-60. PMID: 18046329
- Schito L et al. (2019) Hypoxia and mitochondrial dynamics. J Clin Invest 129(11):4661-4667. PMID: 31647581
- Peers C et al. (2015) HIF in neuronal survival. J Neurochem 133(4):493-501. PMID: 25708295
- Vangeel L et al. (2020) HIF prolyl hydroxylase inhibitors. Pharmacol Ther 209:107452. PMID: 31904376
- Cheng J et al. (2021) HIF-1alpha in Alzheimer's disease. Neurobiol Aging 101:294-305. PMID: 33418498
- Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3):399-408. PMID: 22304911
- Wang GL et al. (1995) Hypoxia-inducible factor 1. Proc Natl Acad Sci USA 92(12):5510-5514. PMID: 7539918
- Sharp FR et al. (2004) HIF-1 and hypoxic preconditioning. J Cereb Blood Flow Metab 24(11):1247-1262. PMID: 15545690
- Zhang H et al. (2008) HIF-1 and mitochondrial dysfunction. Nat Rev Cancer 8(1):51-60. PMID: 18046329
- Schito L et al. (2019) Hypoxia and mitochondrial dynamics. J Clin Invest 129(11):4661-4667. PMID: 31647581
- Peers C et al. (2015) HIF in neuronal survival. J Neurochem 133(4):493-501. PMID: 25708295
- Vangeel L et al. (2020) HIF prolyl hydroxylase inhibitors. Pharmacol Ther 209:107452. PMID: 31904376
- Cheng J et al. (2021) HIF-1alpha in Alzheimer's disease. Neurobiol Aging 101:294-305. PMID: 33418498