HES1 is a protein encoded by the HES1 gene that hes1 is a key notch signaling effector:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
Associated Diseases: [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Neurodevelopmental Disorders](/diseases/neurodevelopmental-disorders)
HES1 is a basic helix-loop-helix (bHLH) transcription factor (280 amino acids) with:
HES1 is a key Notch signaling effector:
HES1 dysregulation contributes to neurodegeneration:
Modulating HES1/Notch signaling is being explored: