Hdac11 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Hdac11 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Histone Deacetylase 11 Protein | |
|---|---|
| Protein Name | Histone Deacetylase 11 |
| Gene | HDAC11 |
| UniProt ID | Q9P0K5 |
| PDB Structure | 4RUI |
| Molecular Weight | 39 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | Class IV Histone Deacetylase |
HDAC11 is the sole member of class IV HDACs, with 347 amino acids. It contains a catalytic domain distinct from class I, II, and III enzymes. The structure reveals a Rossmann-fold-like catalytic core with a zinc-binding motif. HDAC11 is the smallest HDAC with unique structural features.
HDAC11 catalyzes the removal of acetyl groups from lysine residues on histones and non-histone proteins. It regulates gene expression, immune responses, and metabolism. In the brain, HDAC11 may regulate neuronal gene expression and immune responses in glial cells.
| Disease | Mechanism | Evidence |
|---|---|---|
| Cancer | Overexpression in various cancers; promotes tumor growth. | Clinical studies |
| Autoimmune disorders | Altered immune cell gene expression. | Model systems |
| Neurodegeneration | Possible role in neuronal function. | Preliminary studies |
Hdac11 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Hdac11 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.