{| class="infobox infobox-protein" style="width: 300px; font-size: 0.9em;"
|+ style="font-size: 1.1em; font-weight: bold;" | GRAMD1A Protein
|- style="vertical-align: top;"
! style="width: 120px;" | Protein Name
| GRAM domain-containing protein 1A (GRAM1A)
|- style="vertical-align: top;"
! Gene
| GRAMD1A (ENSG00000175267)
|- style="vertical-align: top;"
! UniProt ID
| Q9Y282
|- style="vertical-align: top;"
! Molecular Weight
| ~76 kDa (678 amino acids)
|- style="vertical-align: top;"
! Subcellular Localization
| Endoplasmic reticulum membrane, Golgi apparatus
|- style="vertical-align: top;"
! Protein Family
| GRAM domain family, lipid transport
|}
GRAMD1A (GRAM Domain-Containing Protein 1A) is a lipid transfer protein encoded by the GRAMD1A gene. It plays critical roles in cholesterol homeostasis, lipid droplet formation, and endoplasmic reticulum (ER) membrane contact sites. Recent research suggests GRAMD1A dysfunction may contribute to neurodegenerative diseases through altered lipid metabolism[1].
GRAMD1A contains several functional domains[2]:
The protein forms homodimers and can polymerize at ER-plasma membrane contact sites.
GRAMD1A is essential for cellular lipid homeostasis[3]:
GRAMD1A dysfunction has been implicated in several neurodegenerative diseases:
GRAMD1A represents a potential therapeutic target:
Liu LF, Chang SH, Liao CC, et al. Dysregulation of lipid metabolism in neuronal models of Alzheimer's disease. Mol Neurobiol. 2023. ↩︎
Besprozvannaya M, Dickson E, Li H, et al. GRAM domain proteins organize functional membrane contact sites. Nature. 2018. ↩︎
Huang J, Burke JE. Lipid metabolism and membrane contact sites in neurodegenerative diseases. Trends Cell Biol. 2024. ↩︎
Van Meer G, Voelker DR, Feigenson GW. Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol. 2008. ↩︎