Gng3 Protein — G Protein Subunit Gamma 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| G Protein Subunit Gamma 3 | |
|---|---|
| Protein Name | GNG3 (G protein gamma 3) |
| Gene | GNG3 |
| UniProt ID | P63215 |
| PDB Structure | 1GP2 |
| Molecular Weight | 8 kDa |
| Subcellular Localization | Plasma membrane |
| Protein Family | G protein gamma subunit family |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
GNG3 is a small 71 amino acid protein that undergoes prenylation for membrane localization. It forms a tight dimer with beta subunits.
GNG3 is involved in G protein-coupled receptor signaling, particularly in the brain. It regulates ion channels and second messenger systems.
Altered GNG3 expression is associated with Alzheimer's disease and epilepsy. It affects synaptic plasticity and neuronal excitability.
Research focuses on understanding its role in neuronal function.
The study of Gng3 Protein — G Protein Subunit Gamma 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.