Glut1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| GLUT1 | GLUT1 Protein | SLC2A1 | UniProt | 492 aa | 54.0 kDa | Cell Membrane | SLC Transporter Family |
GLUT1 Protein is a protein involved in neuronal function and signaling relevant to neurodegenerative diseases. It plays important roles in synaptic transmission, ion channel regulation, or cellular metabolism that are critical for neuronal health and function.
Dysregulation of this protein's function or expression contributes to the pathogenesis of Alzheimer's disease, Parkinson's disease, and related neurodegenerative disorders through effects on synaptic plasticity, energy metabolism, or cellular stress response.
GLUT1 is a 492 aa 54.0 kDa Cell Membrane protein belonging to the SLC Transporter Family. 12 transmembrane domains.
Glucose transporter, blood-brain barrier, brain metabolism. These proteins are essential for glucose uptake into the brain.
Alzheimer's Disease: GLUT1 deficiency leads to early-onset AD. VGLUTs are downregulated in AD brain. Oxidative stress is elevated.
Parkinson's Disease: Glucose metabolism is impaired. VGLUTs may be affected in substantia nigra.
ALS: SOD1 mutations cause familial ALS. SV2A is a drug target for ALS.
Epilepsy: SV2A is the target of antiepileptic drugs levetiracetam and brivaracetam.
The study of Glut1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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