Gapdh Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) is a 335-amino acid tetrameric enzyme (approximately 37 kDa per subunit) that catalyzes the sixth step of glycolysis. Beyond its essential role in energy metabolism, GAPDH has been extensively characterized as a multifunctional protein involved in neurodegeneration, apoptosis, and cellular stress responses.
| Attribute | Value |
|---|---|
| Protein Name | Glyceraldehyde-3-Phosphate Dehydrogenase |
| Gene | GAPDH |
| UniProt ID | P04406 |
| PDB ID | 1GAD, 3GPD |
| Molecular Weight | ~37 kDa per subunit |
| Subcellular Location | Cytoplasm, nucleus (under stress) |
| Protein Family | GAPDH family (oxidoreductases) |
The GAPDH monomer contains:
The active enzyme is a tetramer with 4 identical subunits.
The study of Gapdh Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.