Gap43 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Gap43 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Protein Name: Growth Associated Protein 43 (Neuromodulin)
Gene: GAP43
UniProt ID: P17642
PDB ID: 2N2T
Molecular Weight: 23.6 kDa
Subcellular Localization: Plasma membrane, Growth cones, Axon terminals
Protein Family: Neuromodulin family
GAP43 has a distinctive structure adapted for its function:
GAP43 (neuromodulin) is a neuronal phosphoprotein that plays critical roles in axonal growth, nerve terminal development, and synaptic plasticity. It is highly expressed in developing neurons and re-induced during regeneration. GAP43 modulates calmodulin availability, regulates actin cytoskeleton dynamics, and affects neurotransmitter release. Its palmitoylation targets it to the plasma membrane of growth cones.
Altered GAP43 expression is observed in Alzheimer's disease, schizophrenia, and following nerve injury. It serves as a marker for axonal regeneration.
GAP43 represents a potential therapeutic target:
Gap43 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Gap43 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.