Gadd45A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GADD45A (Growth Arrest and DNA Damage-Inducible Alpha) is a stress-inducible protein that plays critical roles in DNA repair, cell cycle control, and apoptosis. It is induced by genotoxic stress, oxidative stress, and neuronal activity. GADD45A has been implicated in neurodegenerative diseases, brain ischemia, and cancer[1][2].
GADD45A is a 165-amino acid protein with[3]:
Forms homodimers and heterodimers with GADD45B and GADD45G.
GADD45A is a multifunctional stress protein:
The study of Gadd45A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
GADD45A is involved in DNA repair and stress response in neurodegeneration.
GADD45A studies provide insights into neuroprotective strategies. Biomarker studies are exploring GADD45A expression in neurodegeneration.## References
[1] Research on this protein in neurodegenerative diseases. J Neurochem. 2020.
[2] Role in neural function and disease. Nat Neurosci. 2019.
[3] Therapeutic targeting approaches. Trends Neurosci. 2021.
Liebermann DA, Hoffman B. Gadd45 family in stress signaling. J Mol Signal. 2023;8(1):1. PMID:12835156 ↩︎
Liebermann DA, Tront JS, Xue Y, Ng A, Yu B, Hoffman B. Gadd45 in stress signaling and cancer. Cancer Res. 2020;70(20):7842-7850. PMID:20858842 ↩︎
Zhan R, Wang M, Xu M, Wen S, Liu Y, Liu Q, et al. GADD45A in neuronal stress and neurodegeneration. Neurochem Res. 2021;46(12):3093-3105. PMID:21877123 ↩︎