| GABRB2 | |
|---|---|
| Gene | GABRB2 |
| UniProt | P47870 |
| Protein Name | GABA-A Receptor Subunit Beta-2 |
| PDB Structures | 6HUP, 6HUO, 7KME |
| Molecular Weight | ~54 kDa |
| Subcellular Localization | Plasma Membrane (Neuronal) |
| Protein Family | Cys-loop receptor family, ligand-gated ion channel |
| Channel Type | Ligand-gated chloride channel |
| Ion Conducted | Cl- |
GABRB2 Protein is a protein that gaba-a receptors are the primary inhibitory neurotransmitter receptors in the central nervous system. the beta-2 subunit-containing receptors play crucial roles in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
The GABRB2 protein encodes the beta-2 subunit of the GABA-A receptor, a member of the Cys-loop ligand-gated ion channel superfamily[1]. GABA-A receptors are pentameric assemblies typically composed of two alpha, two beta, and one gamma or delta subunit.
Key structural features include:
The beta-2 subunit is essential for proper receptor assembly, trafficking, and pharmacological properties. Receptors containing the beta-2 subunit show distinct benzodiazepine sensitivity and gating characteristics[3].
GABA-A receptors are the primary inhibitory neurotransmitter receptors in the central nervous system. The beta-2 subunit-containing receptors play crucial roles in:
GABA-A receptor dysfunction is increasingly recognized in neurodegenerative diseases:
The GABRB2 subunit is a key target for several drug classes:
| Drug Class | Examples | Mechanism | Neurodegeneration Relevance |
|---|---|---|---|
| Benzodiazepines | Diazepam, Lorazepam | Positive allosteric modulators | Anxiety, seizure, muscle spasm |
| Barbiturates | Phenobarbital | Pore block/modulation | Seizure control |
| Neurosteroids | Allopregnanolone | Positive modulation | Epilepsy, depression |
| Inverse Agonists | Flumazenil (partial) | Negative modulation | Investigational |
| GABA Analogs | Gabapentin, Pregabalin | Voltage-gated calcium channel | Neuropathic pain |
GABRB2 Protein is GABA-A receptor beta 2 subunit. It plays roles in neuronal function and has been implicated in various neurological conditions.
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