Gaba A Receptor Alpha 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GABA-A α1 is a subunit of the GABA-A receptor, the major inhibitory neurotransmitter receptor in the central nervous system. The GABA-A α1 subunit (encoded by the GABRA1 gene) is the most abundantly expressed α subunit in the brain and forms part of the majority of synaptic GABA-A receptors. [1]
| Property | Value | [2]
|----------|-------| [3]
| Protein Name | GABA-A Receptor Alpha 1 | [4]
| Gene | GABRA1 | [5]
| UniProt ID | P14867 | [6]
| Molecular Weight | ~51 kDa | [7]
| Structure | Ligand-gated chloride channel (pentameric) |
| Subcellular Localization | Plasma membrane, synapses |
| Brain Expression | Highest in cortex, hippocampus, thalamus |
GABA-A receptors are pentameric ligand-gated chloride channels composed of 19 subunits (α1-6, β1-3, γ1-3, δ, ε, θ, π, ρ1-3):
GABA-A α1 receptor function in the central nervous system:
The study of Gaba A Receptor Alpha 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Rudolph U, GABA-A receptor subtypes: therapeutic potential in Down syndrome (2013). 2013. ↩︎
Mohler H, GABA(A) receptor diversity and pharmacology (2006). 2006. ↩︎
Jacob TC, GABA(A) receptor trafficking and its role in the dynamic maintenance of neuronal inhibition (2008). 2008. ↩︎
Luscher B, GABA(A) receptors: politics and psychiatry (2011). 2011. ↩︎
Nutt DJ, GABA receptors and their therapeutic significance (2020). 2020. ↩︎
Petroski RE, GABA-A receptor alpha1 subunit mutations associated with epilepsy (2015). 2015. ↩︎
Khawaled R, GABA-A alpha1 receptors in Alzheimer's disease (2019). 2019. ↩︎