Gaba A Receptor Theta Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GABRF encodes the theta subunit of GABA-A receptors. Theta-containing receptors are expressed in specific brain regions and have distinct functional properties.
GABA-A Receptor Theta Protein is encoded by the GABRF gene. It is a GABA-A receptor theta subunit. The UniProt ID is Q9UII2.
- Molecular Weight: 56 kDa
- Localization: Plasma membrane, Brain
- PDB Structures: None determined
GABRF encodes the theta subunit of GABA-A receptors. Theta-containing receptors are expressed in specific brain regions and have distinct functional properties.
The protein is expressed in Plasma membrane, Brain and plays important roles in cellular physiology.
GABRF mutations are associated with epilepsy and neurodevelopmental disorders.
Theta subunit-targeted drugs are under development.
The study of Gaba A Receptor Theta Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Stocker M. Calcium-activated potassium channels: molecular diversity and function. Physiological Reviews. 2004;84(3):903-934. PMID:15269336
- Kohler M, Hirschberg B, Bond CT, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996;273(5282):1709-1714. PMID:8781166
- Wulff H, Kolski-Andreaco A. Modulators of small- and intermediate-conductance Ca2+-activated K+ channels. Current Pharmaceutical Design. 2007;13(31):3179-3184. PMID:17979758
- Dessauer CW, Sorscher EJ, Brennan TJ, et al. Isolation and characterization of a novel large conductance calcium-activated potassium channel. Journal of Biological Chemistry. 1998;273(50):33123-33129. PMID:9837872
- Bhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. Journal of Comparative Neurology. 2002;454(3):241-254. PMID:12442319
6.remote Y, Kaczmarek LK. Slack, Slick and Slam channels: roles in neuronal excitability, neuroprotection and neurodegeneration. Brain Research. 2020;1732:146738. PMID:32035170
- Rudy B, McBain CJ. Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends in Neurosciences. 2001;24(9):517-526. PMID:11530637
- Gu N, Vervaeke K, Storm JF. Slack and Slick potassium channels in pyramidal neurons. Neuropharmacology. 2007;52(3):683-688. PMID:17097100