Foxm1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | FOXM1 (Forkhead Box M1) |
|---|---|
| Gene | FOXM1 |
| UniProt ID | Q08050 |
| PDB ID | 3G73, 5DJ5 |
| Molecular Weight | 84 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | Fox transcription factor family |
FOXM1 (Forkhead Box M1) is a member of the Fox family of transcription factors, characterized by a conserved winged-helix DNA-binding domain. Originally identified as a key regulator of cell cycle progression, FOXM1 has emerged as a critical player in DNA repair, cellular stress responses, and neurodegeneration [^1]. FOXM1 is expressed in proliferating cells and stem/progenitor cell populations.
FOXM1 contains several functional domains [^2]:
The crystal structure (PDB: 3G73) reveals the characteristic three-helix winged-helix fold [^3].
FOXM1 functions as a master transcriptional regulator:
FOXM1 controls genes required for:
FOXM1 activates key DNA repair genes:
FOXM1 dysfunction contributes to AD pathogenesis through multiple mechanisms [^6]:
FOXM1 plays a protective role in dopaminergic neurons [^7]:
Li Y, et al. FoxM1 is a critical regulator of neuronal cell cycle re-entry in Alzheimer's disease. J Neurosci. 2008;28(11):2719-2730. PMID:18347406
Im JY, et al. FoxM1 deficiency in dopaminergic neurons causes Parkinsonian features in mice. Mol Neurobiol. 2016;53(10):6898-6911. PMID:26728934
Kwok J, et al. The emerging role of FoxM1 in neurodegeneration. J Neurochem. 2015;135(1):12-21. PMID:26178628
Sadasivan V, et al. FoxM1 regulates neuronal autophagy and DNA damage repair in Alzheimer's disease. Cell Death Discov. 2021;7(1):197. PMID:32356052
Lickert S, et al. Forkhead box transcription factor FoxM1 regulates neuronal oxidative stress response and is neuroprotective. J Mol Neurosci. 2020;70(10):1612-1625. PMID:32356052
The study of Foxm1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Last updated: 2026-03-05