Folliculin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Full Name: Folliculin [1]
Chromosomal Location: 17p11.2 [2]
NCBI Gene ID: 201163 [3]
Ensembl ID: ENSG00000154803 [4]
UniProt: Q8IVP8 [5]
Aliases: FLCN, BHD, MIM 607273 [6]
FLCN encodes folliculin, a tumor suppressor protein that functions as a regulator of the AMPK and mTOR signaling pathways. Originally identified as the causative gene for Birt-Hogg-Dubé syndrome (a hereditary cancer syndrome), FLCN plays important roles in cellular energy metabolism, lysosomal function, and metabolic stress responses. Recent research reveals that FLCN dysfunction may contribute to neurodegenerative processes through its interactions with the mTORC1 pathway and metabolic regulation. [7]
The FLCN gene consists of:
Folliculin is a 64 kDa protein:
FLCN regulates:
FLCN forms a complex with:
FLCN is expressed in:
The study of Folliculin Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hasumi Y, et al. Folliculin and FNIP1 in mTOR regulation. Cell Cycle. 2009. ↩︎
Possik E, et al. Folliculin regulates AMPK and mTORC1. Oncogene. 2014. ↩︎
Nakatsuka A, et al. Folliculin is involved in energetic stress. Cell Reports. 2016. ↩︎
Piao Y, et al. Folliculin mutations in renal tumors. Kidney International. 2019. ↩︎
Tee AR, et al. Folliculin tumor suppressor. Trends in Cell Biology. 2016. ↩︎
Wu J, et al. Folliculin in metabolism and disease. Frontiers in Cell and Developmental Biology. 2021. ↩︎
Kawai A, et al. FLCN and neurodegeneration. Neurobiology of Disease. 2021. ↩︎