{{> infobox .infobox-protein
| name = FIGN Protein
| gene = FIGN
| uniprot = Q9HAW4
| molecular_weight = ~49 kDa
| localization = Cytoplasm, Microtubules
| family = Fign family, AAA ATPase family
}}
{{> infobox is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
FIGN (Fidgetin) is a AAA ATPase family member (~425 amino acids) with an N-terminal microtubule-binding domain and a C-terminal AAA ATPase domain. The protein forms hexameric rings that use ATP hydrolysis to remodel microtubules. FIGN contains a unique domain architecture not found in other fidgetin family members.
In the nervous system, FIGN regulates:
[1] FIGN alterations may contribute to AD through:
[2] In PD, FIGN dysregulation affects:
[3] FIGN mutations are linked to HSP subtypes: