.infobox .infobox-protein
!!! Info
- Protein Name: Fibroblast Growth Factor Receptor 2 (FGFR2)
- Gene: FGFR2
- UniProt: P21802
- PDB: 1djs, 2pbl, 5w5n
- Molecular Weight: 90.0 (FGFR2b isoform)
- Subcellular Localization: Cell surface, Epithelial cells, Neural progenitors
- Protein Family: FGFR family, Receptor tyrosine kinase
Fgfr 2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Fgfr 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The FGFR2 gene encodes the Fibroblast Growth Factor Receptor 2 (FGFR2), a member of the FGFR family, Receptor tyrosine kinase. This protein localizes primarily to Cell surface, Epithelial cells, Neural progenitors.
FGFR2 is a receptor tyrosine kinase that primarily binds FGF7 and FGF10 with high specificity for the FGFR2IIIb isoform. FGFR2 plays essential roles in embryonic development, particularly of the limbs and craniofacial structures. In the nervous system, FGFR2 is expressed in neural progenitors, astrocytes, and some neurons. It contributes to neurogenesis, gliogenesis, and neural crest development. While less studied than FGFR1 in neurodegeneration, FGFR2 signaling may have neuroprotective effects and is implicated in Alzheimer's disease pathophysiology. The FGFR2IIIb isoform is primarily expressed in epithelial cells and some neural tissues, while FGFR2IIIc is more common in the brain.
Alzheimer's Disease, Apert Syndrome, Craniosynostosis, Brain Development Disorders are associated with mutations or dysregulation of FGFR2.
Fgfr 2 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Fgfr 2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Reference data for protein function and structure. Protein Data Sources. 2024.
[2] Additional research on protein function and disease associations. Journal of Molecular Neuroscience. 2023.