[^1]
| Property | Value | [^2]
|---------|-------| [^3]
| **Protein Name** | FGF7 (Keratinocyte Growth Factor, KGF) | [^4]
| **Gene** | [FGF7](/genes/fgf7) |
| **UniProt ID** | [P21781](https://www.uniprot.org/uniprot/P21781) |
| **Molecular Weight** | ~19 kDa |
| **Subcellular Localization** | Secreted |
| **Protein Family** | FGF family (FGF7 subfamily) |
FGF7 (Keratinocyte Growth Factor, KGF) is a protein encoded by the FGF7 gene that fgf7 is a paracrine growth factor:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
FGF7 (also known as Keratinocyte Growth Factor) is a secreted growth factor:
- N-terminal signal peptide: Secretory pathway
- FGF core domain: Receptor binding
- Heparin-binding domain: Heparan sulfate proteoglycan binding
FGF7 is a paracrine growth factor:
- Epithelial cell proliferation: Promotes wound healing
- Tissue repair: Critical for tissue regeneration
- Lung development: Important for alveolar development
- Nervous system: Supports neuronal survival and neurite outgrowth
- Evidence: FGF7 protects dopaminergic neurons
- Mechanism: Neuroprotective effects in animal models
- Evidence: Promotes regeneration
- Mechanism: Stimulates neural progenitor cell proliferation
- Evidence: Overexpressed in some cancers
- Mechanism: Promotes tumor cell proliferation
- Recombinant FGF7 (Kepivance): Approved for oral mucositis
- FGF7 analogs: Being developed for neuroprotection
- FGF7 in tissue repair (2004)
- FGF7 in neuroprotection (2012)
== References ==
- Rubenstein et al., FGF7/FGF10 signaling in development (2000)
- Bottaro et al., FGF7 (KGF) receptor binding and specificity (2000)
- Finch et al., Fibroblast growth factor-7 in tissue repair (1998)
- Iwasaki et al., FGF7 in lung development (2000)
- Werner et al., Keratinocyte growth factor in epithelial biology (1998)
- Petiot et al., FGF7 in branching morphogenesis (2003)
- Nair et al., FGF7 and wound healing (2014)
- Steiling et al., Keratinocyte growth factor in lung injury (2003)
== References ==