Ferritin Light Chain Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Ferritin Light Chain (FTL) is a subunit of the iron storage protein ferritin. Mutations in FTL cause Neuroferritinopathy (also called Ferritinopathy), a rare autosomal dominant disorder characterized by progressive movement disorders and brain iron accumulation.
| Attribute | Value |
|---|---|
| Protein Name | Ferritin Light Chain |
| Gene Symbol | FTL |
| UniProt ID | P02792 |
| PDB Structure | 2FHL, 3CA0 |
| Molecular Weight | ~20 kDa (light chain) |
| Subcellular Localization | Cytoplasm |
| Protein Family | Ferritin family |
Ferritin forms a 24-subunit shell (icosahedral):
Each subunit:
Ferritin is essential for iron homeostasis:
In the brain:
The 460dupA mutation in the FTL coding region causes:
Clinical features:
Treatments include:
The study of Ferritin Light Chain Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Ferritin light chain (FTL) plays critical roles in neurodegeneration:
Targeting ferritin and iron homeostasis offers therapeutic opportunities:
This page was created on 2026-03-04
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